Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.
In: Environment International, Jg. 117 (2018-08-01), S. 339-347
Online
academicJournal
Zugriff:
Background Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. Methods We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003–2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1–3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years. Results Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ∑PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI −40.8%, −11.3%) in TSH. A ten-fold increase in prenatal ∑PBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT 3 ). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T 4 (FT 4 ) in males. Prenatal ∑PBDEs were not associated with TT 4 , FT 4 , or total T 3 . Conclusions These findings suggest an inverse relationship between prenatal ∑PBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males. [ABSTRACT FROM AUTHOR]
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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.
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Autor/in / Beteiligte Person: | Vuong, Ann M. ; Braun, Joseph M. ; Webster, Glenys M. ; Thomas Zoeller, R. ; Hoofnagle, Andrew N. ; Sjödin, Andreas ; Yolton, Kimberly ; Lanphear, Bruce P. ; Chen, Aimin |
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Zeitschrift: | Environment International, Jg. 117 (2018-08-01), S. 339-347 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0160-4120 (print) |
DOI: | 10.1016/j.envint.2018.05.019 |
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