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Author Response: Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

Yan, Hui ; Liu, Yao ; et al.

2024

unknown

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Figure 1. VTAGad67+ neurons project to multiple areas in the brain. ; (a) Schematic of AAV injection to express Cre-inducible hrGFP in Gad67-Cre mice. The dotted brain map area is shown to the right. White rectangular area is shown below. (b) Immunohistochemical studies showing expression of hrGFP in Gad67+ neurons (arrowhead), but not in the nearby DA (arrow) neurons. (c) Pie chart showing the percent of hrGFP expression in DA and non-DA neurons in the VTA (n = 4 mice). (d and e) Expression of hrGFP in VTAGad67+ neurons and some of their projected brain areas are shown. (f) Table showing the comparative scoring of hrGFP signals across different brain areas. Abbreviations- AcbC: Nucleus accumbens core, AcbSh: Nucleus accumbens shell, BLA: Basolateral amygdala, CeA: Central nucleus of the amygdala, CM: Central medial thalamic nucleus, CnF: Cuneiform nucleus, CPu: Caudate putamen (striatum), DEn: Dorsal endopiriform nucleus, DR: Dorsal raphe nucleus, IMD: Intermediodorsal thalamic nucleus, InG: Intermediate gray layer of the superior colliculus, LH: Lateral hypothalamus, LPO: Lateral preoptic area, MM: Medial mammillary nucleus, Pa4: Paratrochlear nucleus, PAG: Periaqueductal gray, PF: Parafascicular thalamic nucleus, PnO: Pontine reticular nucleus, SubB: Subbrachial nucleus, VLL: Ventral nucleus of the lateral lemniscus, VP: Ventral pallidum, Xi: Xiphoid thalamic nucleus and xscp: Decussation of the superior cerebellar peduncles. DAPI (4′,6-diamidino-2-phenylindole) staining was used to label nuclear DNA and also to assist understanding of the anatomical position of VTAGad67+ neuronal projections.

2019

unknown

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Figure 3. Substitutions at SET domain catalytic residues in bony fish PRDM9 genes. ; (a) Lineages within bony fish carrying substitutions at each of three tyrosine residues involved in H3K4me3 catalysis in human PRDM9 are shown in blue, yellow and red. (b) Lineages carrying substitutions at one, two or three of these residues are shown in red, pink and blue respectively. All PRDM9β genes as well as a partial PRDM9 ortholog from holostean fish carry one or more substitutions at these residues. The PRDM9β gene from Xiphophorus is indicated by the presence of asterisk.

2017

unknown

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Figure 4. Patterns of recombination and PRDM9 evolution in swordtail fish. ; (a) The ZF array of PRDM9 appears to be evolving slowly in Xiphophorus, with few changes over 1 million years of divergence (Cui et al., 2013; Jones et al., 2013). (b) PRDM9 is upregulated in the germline relative to the liver in X. birchmanni (circles) and X. malinche (squares; panel shows three biological replicates for each species). (c) The computationally-predicted PRDM9 binding sites is not unusually associated with H3K4me3 peaks in testes (d) Crossover rates increase near H3K4me3 peaks in testis (e) Crossover rates increase near CGIs (f) Crossover rates do not increase near computationally-predicted PRDM9 binding sites (see Figure 4—figure supplement 3 for comparison). Crossover rates were estimated from ancestry switchpoints in naturally occurring hybrids between X. birchmanni and X. malinche (see Materials and methods).

2017

unknown

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Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

Yan, Hui ; Liu, Yao ; et al.

2023

Online unknown

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Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

Yan, Hui ; Liu, Yao ; et al.

2023

unknown

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Figure 4. Distribution of sites in significant linkage disequilibrium throughout the Xiphophorus genome. ; Schematic of regions in significant LD in both populations at FDR 5%. Regions in blue indicate regions that are positively associated in both populations (conspecific in association), regions in black indicate associations with different signs of R in the two populations, while regions in red indicate those that are negatively associated in both populations (heterospecific in association). Chromosome lengths and position of LD regions are relative to the length of the assembled sequence for that linkage group; most identified LD regions are

2014

unknown

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Author response: The skeletal muscle circadian clock regulates titin splicing through RBM20

Riley, Lance A ; Zhang, Xiping ; et al.

2022

unknown

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Author response: Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

Chi, Jingyi ; Lin, Zeran ; et al.

2021

unknown

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Author response: MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

Hodge, Brian A ; Zhang, Xiping ; et al.

2019

unknown

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Author response: Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

Terry, Erin E ; Zhang, Xiping ; et al.

2018

unknown

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Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

Haba, Yuki ; Baker, Zachary ; et al.

In: 10.7554/eLife.24133 ; 2952421220 ; 28726634 ; oai:pubmedcentral.nih.gov:5519329 ; 10.1101/093096 ; 2562414464 ; 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 ; 10|doajarticles::918ee31b7bf0a155228fcc9e17783d80 ; 10|openaire____::8ac8380272269217cb09a928c8caa993 ; 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a ; 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 ; 10|openaire____::55045bd2a65019fd8e6741a755395c8c ; openaire____::1256f046-bf1f-4afc-8b47-d0b147148b18 ; 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357, 2017

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