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363 Treffer

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  1. Detailansicht für Treffer 1 öffnen
    Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue .
    Wang, M ; Kuldharan, S ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, 2024-04-26
    academicJournal
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  2. Detailansicht für Treffer 2 öffnen
    Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model.
    Peng, J ; Ladumor, MK ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 50 (2022-05-01), Heft 5, S. 613
    academicJournal
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  3. Detailansicht für Treffer 3 öffnen
    Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs.
    Pike, A ; Jones, B ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 49 (2021-09-01), Heft 9, S. 736
    academicJournal
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  4. Detailansicht für Treffer 4 öffnen
    Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat.
    Schmitt, MV ; Reichel, A ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 49 (2021), Heft 1, S. 53
    academicJournal
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  5. Detailansicht für Treffer 5 öffnen
    Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound.
    Jusko, WJ ; Molins, EAG ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 48 (2020-10-01), Heft 10, S. 894
    academicJournal
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  6. Detailansicht für Treffer 6 öffnen
    Concentration Dependence of the Unbound Partition Coefficient Kp <subscript>uu</subscript> and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
    Trünkle, C ; Lechner, C ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 48 (2020-07-01), Heft 7, S. 553
    academicJournal
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  7. Detailansicht für Treffer 7 öffnen
    Regulatory Recommendations for Calculating the Unbound Maximum Hepatic Inlet Concentration: A Complicated Story with a Surprising and Happy Ending.
    Parkinson, A
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 47 (2019-07-01), Heft 7, S. 779
    editorialOpinion
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  8. Detailansicht für Treffer 8 öffnen
    Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.
    Barr, JT ; Lade, JM ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 47 (2019-04-01), Heft 4, S. 419
    academicJournal
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  9. Detailansicht für Treffer 9 öffnen
    Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.
    Riccardi, K ; Ryu, S ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 46 (2018-04-01), Heft 4, S. 415
    academicJournal
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  10. Detailansicht für Treffer 10 öffnen
    Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties.
    Kalvass, JC ; Phipps, C ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 46 (2018-04-01), Heft 4, S. 458
    academicJournal
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  11. Detailansicht für Treffer 11 öffnen
    Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins.
    Yoshikado, T ; Toshimoto, K ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 45 (2017-07-01), Heft 7, S. 779
    academicJournal
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  12. Detailansicht für Treffer 12 öffnen
    Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations.
    Riede, J ; Poller, B ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 45 (2017-05-01), Heft 5, S. 523
    academicJournal
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  13. Detailansicht für Treffer 13 öffnen
    Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration.
    Hopkins, AM ; Moghaddami, M ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 45 (2017), Heft 1, S. 8
    academicJournal
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  14. Detailansicht für Treffer 14 öffnen
    When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?
    Stern, ST ; Martinez, MN ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 44 (2016-12-01), Heft 12, S. 1934
    academicJournal
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  15. Detailansicht für Treffer 15 öffnen
    Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.
    Riccardi, K ; Li, Z ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 44 (2016-10-01), Heft 10, S. 1633
    academicJournal
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  16. Detailansicht für Treffer 16 öffnen
    Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.
    Ghosh, A ; Maurer, TS ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 42 (2014-10-01), Heft 10, S. 1599
    academicJournal
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  17. Detailansicht für Treffer 17 öffnen
    Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters.
    Kodaira, H ; Kusuhara, H ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 42 (2014-06-01), Heft 6, S. 983
    academicJournal
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  18. Detailansicht für Treffer 18 öffnen
    Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.
    Pfeifer, ND ; Harris, KB ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 41 (2013-11-01), Heft 11, S. 1949
    academicJournal
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  19. Detailansicht für Treffer 19 öffnen
    Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.
    Liu, X ; Van Natta, K ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 37 (2009-04-01), Heft 4, S. 787
    academicJournal
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  20. Detailansicht für Treffer 20 öffnen
    Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios.
    Kalvass, JC ; Maurer, TS ; et al.
    In: Drug metabolism and disposition: the biological fate of chemicals, Jg. 35 (2007-04-01), Heft 4, S. 660
    academicJournal
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